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: https://doi.org/10.5281/zenodo.19597952

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INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH

A Single Case Study on Ayurvedic Detox Drinks for Weight Loss via Gut–Brain

Axis Regulation

Dr. Krishna P. Thorat Kullolli ¹, Dr. Vivekanand Mohan Kullolli ²

¹HOD And Professor ,Department Of Rognidan Evum Vikriti Vigyana ,Indian Institute Of Ayurved, Research

And Hospital Rajkot.

²HOD And Professor ,Department Of Shalya Tantra,Indian Institute Of Ayurved, Research And Hospital Rajkot.

Corresponding Author: Dr.Krishna P. Thorat Kullolli

ORCID ID: 0000-0002-5791-372X

Article Info: Article Received on : 28/03/2026

Article Reviewed on: 01/04/2026

Article Published on : 15/04/2026

Cite this article as: - Kulloli, K., & Kulloli, V. (2026). A Single Case Study on Ayurvedic Detox Drinks for Weight Loss via Gut–

Brain Axis Regulation. International Journal of Diagnostics And Research, 3(3), 130–141.

https://doi.org/10.5281/zenodo.19597952

Abstract

Background: The gut–brain axis is a bidirectional communication system linking gastrointestinal

physiology with emotional and cognitive centers. Disturbances in this axis contribute to altered appetite

regulation, emotional eating, and metabolic disorders. Ayurveda conceptualizes this relationship through

Agni (digestive fire), Ama (metabolic toxins), and Manasika Bhava (psychological factors), where impaired

Agni leads to Ama accumulation and Medodhatu vriddhi, ultimately manifesting as Sthoulya

(overweight/obesity).

Objective: To evaluate the efficacy of Ayurvedic detox drinks in promoting weight loss by modulating the

gut–brain axis and restoring Agni.

Methods: A single-case clinical study was conducted on a 38-year-old female (BMI 28.1 kg/m²) presenting

with Adhmana (bloating), Alasya (lethargy), impaired concentration, restlessness, and emotional eating

behavior. A 30-day intervention protocol comprising seven Ayurvedic detox drinks—Jeera water, Ajwain

water, Saunf water, Methi infusion, Triphala decoction, Lemon–Honey Ushnodaka, and Jeera–Ajwain–

Saunf combination water—was administered alongside dietary regulation (Laghu Ahara) and lifestyle

modifications including pranayama and mindful eating.

Results: After 30 days, the patient showed a reduction of 3.8 kg body weight, improvement in digestive

function, normalization of bowel habits, reduced bloating, enhanced satiety, and significant decline in

emotional eating episodes. Psychological parameters such as restlessness and lack of concentration also

improved, indicating better mind–gut coordination.

Conclusion: Ayurvedic detox drinks effectively restored Agni, facilitated Ama Pachana, and contributed to

regulation of the gut–brain axis, resulting in sustainable weight loss and improved psychological well-being.

This integrative approach highlights the relevance of Ayurveda in managing metabolic disorders through

holistic gut–mind modulation.

Keywords: Gut–brain axis, Agni, Ama, Sthoulya, detox drinks, emotional eating, Ayurveda, Ushnodaka,

Medodhatu, gut–mind modulation.

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classical texts, Mandagni (low digestive fire) leads

to improper digestion and formation of Ama, which

obstructs bodily channels (Srotorodha) and results

in Medodhatu vriddhi (excess fat accumulation) ^[6].

Sthoulya is described as a Santarpanajanya Vyadhi

(disease due to over-nourishment), involving Kapha

predominance and metabolic imbalance^[7].

Introduction :

Overweight and obesity are emerging as major

public health concerns worldwide, associated with

increased risk of metabolic disorders such as type 2

diabetes mellitus, cardiovascular diseases, and

psychological disturbances. The Body Mass Index

(BMI) remains a widely used parameter to classify

overweight (25–29.9 kg/m²) and obesity (>30

kg/m²)^[1]. However, recent scientific advances

indicate that obesity is not merely a result of caloric

imbalance but involves complex neuro-hormonal

and microbial interactions.

Furthermore, Ayurveda recognizes the influence of

Manasika Bhava (psychological factors) such as

Chinta (stress), Shoka (grief), and Rajas–Tamas

dominance, which lead to Ati Ahara (overeating)

and disturbed digestive function^[8]. Thus, the

Ayurvedic framework aligns closely with modern

understanding of the gut–brain axis.

The concept of the Gut–brain axis has gained

significant attention in understanding appetite

Among various therapeutic approaches, Ahara

regulation,

emotional

eating,

and

metabolic

(diet),

(medication) play a central role. Ayurvedic

detoxification strategies, particularly through

simple herbal drinks, aim at Agni Deepana

(enhancing digestion), Ama Pachana (toxin

Vihara

(lifestyle),

and

Aushadha

homeostasis. This axis represents a bidirectional

communication network between the central

nervous system and gastrointestinal tract mediated

through neural (vagus nerve), endocrine (hormones

like ghrelin and leptin), and immune pathways^[2].

Dysregulation of this axis leads to altered satiety

signalling, increased cravings, and emotional eating

digestion), and Kapha–Medohara action (fat

reduction). These interventions are economical,

safe, and suitable for long-term use.

behaviour,

contributing

to

overweight

and

obesity^[3].The role of gut microbiota in obesity has

also been extensively studied. Alterations in

microbial composition (dysbiosis) affect energy

extraction, fat storage, and inflammatory pathways,

further influencing brain function and behaviour^[4].

Stress and emotional disturbances activate the

This study explores the role of Ayurvedic detox

drinks in regulating the gut–brain axis and

promoting sustainable weight loss in an overweight

individual.

Review of Literature :

Overweight

and

obesity

are

multifactorial

hypothalamic–pituitary–adrenal

(HPA)

axis,

conditions influenced not only by excessive caloric

intake but also by neuroendocrine, microbial, and

psychological mechanisms. The Body Mass Index

(BMI) remains a standard tool for classifying

overweight, yet it does not fully explain the

increasing cortisol levels and promoting visceral fat

accumulation^[5].

comprehensive

Ayurveda

provides

a

explanation

of overweight

(Sthoulya) through the concepts of Agni, Ama,

Dosha, and Dhatu metabolism. According to

underlying

metabolic

complexity^[9].

Recent

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advances highlight the role of the Gut–brain axis, a

resulting in fat accumulation and lethargy^[15,16]

.

dynamic communication network linking the

Classical texts such as Charaka Samhita and

Sushruta Samhita emphasize that Sthoulya is a

Santarpanajanya Vyadhi, caused by excessive

nourishment and sedentary habits. Additionally,

Ayurveda recognizes the role of Manasika factors,

where psychological disturbances such as Chinta

(stress), Shoka (grief), and Rajas–Tamas imbalance

lead to Ati Ahara (overeating) and disturbed

digestion, closely paralleling the modern concept of

central

nervous

system

with

gastrointestinal

function through neural, hormonal, and immune

pathways. This axis plays a crucial role in

regulating appetite, satiety, and emotional behavior.

Dysregulation of gut–brain signaling is associated

with altered secretion of hormones such as ghrelin

and leptin, leading to increased hunger, reduced

satiety,

and

emotional

eating

patterns

that

contribute to weight gain^[10,11]

.

emotional eating^[17]

.

The gut microbiota has emerged as a key

component in obesity pathophysiology. Alterations

in microbial diversity, known as dysbiosis,

influence energy extraction, fat storage, and

inflammatory responses. Studies have shown that

microbial metabolites such as short-chain fatty

The concept of Agni is central to Ayurvedic

physiology and metabolism. Proper functioning of

Agni ensures efficient digestion, absorption, and

assimilation of nutrients, while impaired Agni leads

to Ama formation and metabolic disorders.

Therefore, therapeutic strategies in Ayurveda focus

on Agni Deepana (enhancing digestive fire) and

acids

affect

neurotransmitter

production,

particularly serotonin, which is largely synthesized

in the gut and plays a significant role in mood

regulation and eating behavior^[12,13]. Furthermore,

chronic stress activates the hypothalamic–pituitary–

adrenal (HPA) axis, increasing cortisol levels that

promote visceral fat accumulation and disrupt

metabolic homeostasis^[14]. These findings establish

a strong link between psychological stress, gut

function, and obesity.

Ama

Pachana

(detoxification)

as

primary

approaches to manage overweight and related

conditions^[18]. This aligns with modern approaches

that aim to improve gut health and metabolic

regulation.

Ayurvedic detox drinks have been traditionally

used as simple yet effective interventions to restore

digestive balance and metabolic function. Jeera

(Cuminum cyminum) has been shown to enhance

digestive enzyme activity and improve metabolism,

thereby aiding in weight management^[19]. Ajwain

(Trachyspermum ammi) exhibits carminative and

Ayurveda describes overweight under the condition

of Sthoulya, which is primarily a result of Kapha

dosha predominance and Medodhatu vriddhi. The

fundamental cause is Mandagni (diminished

digestive fire), leading to improper digestion and

formation of Ama (metabolic toxins). Ama

obstructs bodily channels (Srotorodha), impairing

nutrient transport and metabolism, ultimately

digestive

properties,

reducing

bloating

and

supporting gut function^[20]. Saunf (Foeniculum

vulgare) acts as a mild digestive and coolant,

improving gastrointestinal motility and reducing

acidity^[21]. Methi (Trigonella foenum-graecum) has

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demonstrated hypoglycemic and hypolipidemic

effects, enhancing satiety and reducing caloric



Emotional eating (regardless of mood)

Body image dissatisfaction

intake^[22]

.

Triphala,

a

classical

polyherbal

for its

Anthropometric Assessment:

formulation,

is widely

recognized



Weight = 72 kg

detoxifying, antioxidant, and gut microbiota-

modulating effects, making it beneficial in

Height = 5 ft 3 inch = 1.60 m

BMI Calculation:

metabolic disorders^[23]

.

BMI= Weight/ Height²= 72/( 1.60)²= 28.1 kg/m²

Additionally,

Lemon–Honey

Ushnodaka,

a

Interpretation: Overweight (Pre-obese stage)

classical Ayurvedic preparation, is described as an

effective Ama Pachaka and Medohara (fat-

reducing) remedy, stimulating metabolism and

facilitating weight loss^[24]. The combination of

Jeera–Ajwain–Saunf provides synergistic effects in

enhancing digestion, reducing gas formation, and

controlling cravings, thereby supporting both

physical and psychological aspects of weight

Roga–Rogi Pariksha :

Clinical Interpretation (Ayurvedic

Perspective)

Predisposition to weight gain, slower

metabolism, tendency for Medodhatu

accumulation

Leads to heaviness, lethargy, bloating

(Adhmana), irregular digestion

Increased adiposity, poor muscle tone

Parameter

Assessment

Prakriti (Constitution)

Kapha–Pitta Prakriti

Vikriti (Current

Imbalance)

Sara (Tissue Quality)

Samhanana (Body

Build)

Kapha Vriddhi with Vata

Anubandha

Meda Sara Vriddhi

Madhyama to Sthula

Moderate to obese body frame

Overweight (Pre-obese stage)

Pramana

(Anthropometry)

Weight: 72 kg, Height: 1.60 m,

BMI: 28.1 kg/m²

Improper dietary adaptation leading to Ama

formation

Low mental resilience, emotional eating

tendency

Satmya (Adaptability)

Satva (Mental Strength)

Asatmya to heavy, oily foods

Avara Satva

Abhyavaharana Shakti:

Increased; Jarana Shakti:

Decreased

Ahara Shakti (Dietary

Capacity)

High intake but poor digestion (Mandagni)

management^[25]

.

Vyayama Shakti

(Exercise Capacity)

Avara (Low)

Easily fatigued, reduced physical endurance

Root cause of Ama formation and metabolic

disturbance

Manifested as bloating, heaviness, lethargy

Irregular bowel habits with occasional

constipation

Sticky, foul-smelling stools indicating Ama

No major urinary pathology

Classical sign of Ama

Overall, both modern scientific evidence and

Ayurvedic principles converge on the importance

of gut health and its interaction with the brain in

regulating body weight. Ayurvedic detox drinks, by

improving Agni, eliminating Ama, and balancing

Doshas, offer a holistic and sustainable approach to

modulating the gut–brain axis and managing

overweight conditions effectively.

Agni (Digestive Fire)

Ama (Toxic Metabolites)

Koshtha (Bowel Nature)

Mandagni

Present (Saama Avastha)

Madhyama to Krura

Mala (Stool)

Mutra (Urine)

Jihva (Tongue)

Shabda (Speech)

Sparsha (Skin)

Drik (Eyes)

Akruti (Body

Appearance)

Nidra (Sleep)

Saama Mala

Normal

Saama (coated)

Normal

Snigdha, slightly cold

Slight dullness

Sthula, Meda accumulation in

abdomen & hips

Disturbed

Chanchalata (restlessness),

emotional instability

Preference for Madhura,

Snigdha Ahara

Medovaha & Annavaha Srotas

Dushti

Amashaya

Abhyantara Roga Marga

Sthoulya (Overweight)

Kapha Pradhana with Vata

involvement

Meda Dhatu

Mandagni

Adhmana, Alasya, Angagaurava

Rajas & Tamas Vriddhi

No abnormality

Kapha dominance

Reflects low metabolic activity

Typical Sthoulya presentation

Linked to Rajas–Tamas imbalance

Leads to emotional eating (Ati Ahara)

Manasika Bhava

Ruchi (Taste

Preference)

Kapha aggravating diet

Srotas Dushti

Impaired fat metabolism and digestion

Udbhava Sthana

Vyadhi Marga

Roga Swaroopa

Origin of disease in digestive system

Internal systemic disorder

Santarpanajanya Vyadhi

Case Presentation :

Dosha Involvement

Metabolic slowdown + bloating

Patient Details:

Dushya Involved

Agni Dushti Type

Ama Lakshana

Manas Dosha

Excess fat accumulation

Core pathology

Classic signs of Ama



Age: 38 years

Emotional eating, lack of control

Gender: Female

Chief Complaints:

Materials and Methods :

Study Design:



Bloating (Adhmana)

Weight gain

This study was designed as a single-case clinical

study conducted over a period of 30 days to

evaluate the effect of selected Ayurvedic detox

drinks on weight management through gut–brain

Lethargy (Alasya)

Loss of concentration

Restlessness (Chanchalata)

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axis regulation. The intervention focused on Agni

Deepana (enhancing digestive fire), Ama Pachana

(detoxification), and Kapha–Medohara action (fat

metabolism).



Triphala churna

Lemon (Citrus limon)

Honey (Madhu)

Warm water (Ushnodaka)

Case Selection:

Method of Preparation of Detox Drinks :

All drinks were freshly prepared daily and

administered only once in the morning on an empty

stomach, as per the 30-day schedule.

1. Jeera Water

Inclusion Criteria:



Female patient aged 38 years

BMI between 25–30 kg/m² (overweight

category)



Presence of symptoms such as:

 Adhmana (bloating)

 Alasya (lethargy)



1 tsp jeera boiled in 200 ml water for 5–7

minutes



Filtered and consumed warm

 Emotional eating

2. Ajwain Water

 Loss of concentration

 Restlessness



1 tsp ajwain boiled in 200 ml water

Reduced to 150 ml and consumed warm

Exclusion Criteria :

3. Saunf Water



Endocrine disorders (e.g., hypothyroidism,



1 tsp saunf soaked overnight in 200 ml

diabetes mellitus)

water



Pregnancy or lactation



Slightly warmed before consumption

Chronic systemic illness

Patients on weight-loss medications

4. Methi Water



1 tsp methi seeds soaked overnight

Water consumed along with chewed seeds

Ethical Consideration



Informed consent was obtained from the

5. Triphala Decoction

patient prior to initiation of the study

The intervention used safe, dietary-based

Ayurvedic preparations with no known

adverse effects



½ tsp Triphala churna boiled in 200 ml

water

Reduced to 100 ml and consumed lukewarm

6. Lemon–Honey Ushnodaka



1 glass warm water + ½ lemon juice + 1 tsp

honey

Materials Used :

All ingredients were easily available kitchen-based

Ayurvedic

dravyas,

ensuring

safety

and



Consumed immediately

compliance:

7. Jeera–Ajwain–Saunf Combination Water



Jeera (Cuminum cyminum)



½ tsp each of jeera, ajwain, and saunf

Boiled in 300 ml water and reduced to 200

ml

Ajwain (Trachyspermum ammi)

Saunf (Foeniculum vulgare)

Methi (Trigonella foenum-graecum)

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Intervention Protocol (30-Day Plan) :

The patient was administered one detox drink per

day in a rotating pattern, ensuring variety and

sustained therapeutic effect.

Assessment Criteria :

Assessment

Method

Digital

weighing scale

Weight/Height²

calculation

Ayurvedic

Correlation

Medodhatu

vriddhi

Sthoulya

classification

Parameter

Type

Grading Criteria

Actual value recorded

Body Weight

(kg)

Objective

<25 Normal,

25–29.9 Overweight, ≥30 Obese

0 = None

1 = Mild (occasionally)

2 = Moderate (daily discomfort)

3 = Severe (persistent)

0 = Normal

1 = Slightly reduced

2 = Irregular

3 = Poor digestion

BMI (kg/m²)

Ama

accumulation,

Vata-Kapha dushti

Bloating

(Adhmana)

Patient-

reported

Subjective

Week-wise Schedule :

Appetite

(Agni Bala)

Patient

feedback

Mandagni

0 = Controlled

Detox Drink

Day

Frequency

Subjective of hunger &

cravings

Satiety /

Cravings

1 = Occasional

2 = Frequent

3 = Uncontrolled

0 = Absent

1 = Rare

2 = Frequent

3 = Continuous (irrespective of mood)

0 = Active

1 = Mild fatigue

2 = Moderate lethargy

3 = Severe lethargy

0 = Good

1 = Mild difficulty

2 = Moderate difficulty

3 = Poor concentration

0 = Calm

1 = Mild

2 = Moderate

3 = Severe

0 = Regular

1 = Slight irregularity

2 = Constipation/loose

3 = Severe irregularity

0 = Normal

1 = Slightly sticky

2 = Sticky/foul smell

3 = Highly abnormal

0 = Clean

1 = Thin coating

2 = Moderate coating

3 = Thick coating

0 = Sound sleep

1 = Mild disturbance

2 = Interrupted

3 = Poor sleep

Rajas dominance,

Medo vriddhi

(Morning Empty Stomach)

Emotional

Eating

Behavioral

Subjective

Manasika dushti

(Rajas–Tamas)

observation

Lemon–Honey Ushnodaka

Jeera Water

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Daily

Subjective activity

level

Energy Levels

(Alasya)

Kapha vriddhi,

Ama

Concentration

(Manas Bala)

Self-reported

Subjective

Rajas–Tamas

imbalance

focus

Ajwain Water

Restlessness

(Chanchalata)

Mental state

Subjective

Vata + Rajas

aggravation

evaluation

Saunf Water

Bowel Habits

Objective/ Frequency &

(Mala Pravritti) Subjective consistency

Agni dushti,

Ama

Methi Water

Stool Nature

Subjective Observation

(Mala Swarupa)

Saama Mala

Triphala Decoction

Jeera–Ajwain–Saunf Water

Tongue Coating

Objective Visual inspection

(Jihva)

Ama presence

Manas imbalance

Kapha dominance

This 7-day cycle was repeated for 4 weeks (30

days)

Sleep (Nidra)

Subjective Sleep pattern

0 = Good

Physical Activity

Tolerance

1 = Mild fatigue

2 = Moderate limitation

3 = Poor tolerance

0 = Normal

Subjective Exercise capacity

Ahara:

Visual &

Objective

1 = Mild

2 = Moderate

3 = Severe

0 = Excellent

1 = Good

2 = Average

3 = Poor

Medodhatu

vriddhi

Abdominal Fat

Deposition

anthropometric



Laghu (light), warm, freshly prepared food

Avoid:

Overall

Well-being

Patient

Subjective

Ojas status

self-rating

 Guru

(heavy),

Snigdha

(oily),

Observation (Day-wise Progression) :

processed food

Day 0

(Baseline)

Day 15 (Mid

Assessment)

Day 30 (Final

Assessment)

Ayurvedic

Interpretation

Gradual Medodhatu

Kshaya

Reduction in Sthoulya

Ama Pachana, Vata-

Kapha balance

Parameter

 Excess Madhura rasa (sweets)

Recommended:

Weight (kg)

72 kg

28.1

70.1 kg

27.4

68.2 kg

26.6

BMI (kg/m²)

Bloating

(Adhmana)

Appetite (Agni

Bala)



Severe

Moderate

Mild

 Yavagu (light gruel)

 Green vegetables

Poor

(Mandagni)

Uncontrolled

Emotional Eating Frequent (daily)

Irregular but

improving

Reduced

Normal (Samagni)

Agni Deepana

Cravings

Controlled

Rare

Manas stabilization

Rajas–Tamas reduction

Occasional

Energy Levels

Severe lethargy

(Alasya)

 Takra (buttermilk)

Moderate

Improved

Kapha reduction

Manas balance

Moderate

improvement

Concentration

Poor

High

Good focus

 Early dinner before 8 pm

Restlessness

(Chanchalata)

Bowel Habits

Moderate

Improving

Minimal

Regular

Normal

Vata–Rajas balance

Agni correction

Ama reduction

Vihara :

Irregular

Sticky (Saama

Mala)

Stool Nature

Semi-normal



30 minutes brisk walking daily

Pranayama (Anulom Vilom, Bhramari)

Mindful eating (slow chewing,

Tongue Coating

Sleep (Nidra)

Thick coating Moderate coating

Disturbed

Mild coating

Sound sleep

Ama clearance

Manasika balance

Increased Vyayama

Shakti

Improved

Physical Activity

Tolerance

Low

Moderate

Good

no

Abdominal Fat

Overall Well-being

Marked

Poor

Slight reduction Visible reduction Medodhatu reduction

Improved

Good

Ojas improvement

distractions)



Fixed meal timings

Adequate sleep hygiene

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enhanced Vyayama Shakti. Sleep patterns also

normalized, shifting from disturbed to sound sleep,

Results:

The present case study demonstrated significant

clinical improvement following the 30-day

further

supporting

mental

and

physiological

stabilization. Overall, the intervention resulted in

significant improvement in Agni, reduction of

Ama, balancing of Dosha (particularly Kapha), and

enhancement of Ojas, leading to sustainable weight

loss and improved well-being. These findings

highlight the effectiveness of Ayurvedic detox

drinks in modulating the gut–brain axis and

managing overweight conditions holistically.

Ayurvedic detox intervention. There was a gradual

and sustained reduction in body weight from 72 kg

at baseline to 68.2 kg at Day 30, accounting for a

total weight loss of 3.8 kg (5.27%). The Body Mass

Index (BMI) correspondingly decreased from 28.1

kg/m² to 26.6 kg/m², indicating improvement

within the overweight category and reflecting

Medodhatu Kshaya.

Discussion :

Digestive function showed marked enhancement,

with the patient initially presenting with Mandagni,

characterized by poor appetite, bloating, and

heaviness. By the end of the intervention, digestion

normalized to Samagni, as evidenced by improved

appetite, reduction in bloating from severe to mild,

and regularization of bowel habits. Clinical features

of Ama, including coated tongue, sticky stools

(Saama Mala), and lethargy (Alasya), were

significantly reduced, indicating effective Ama

Pachana and Srotoshodhana.

The present case study demonstrates that a

structured 30-day regimen of Ayurvedic detox

drinks can produce significant improvements in

both metabolic and psychological parameters

associated with overweight, supporting the concept

of

gut–brain

axis

regulation

through

Agni

modulation and Ama Pachana. The observed

outcomes—including weight reduction, improved

digestion, reduced bloating, and better control over

emotional eating—can be explained through an

Notably, there was substantial improvement in

parameters related to the gut–brain axis. Emotional

eating behavior, which was initially frequent and

independent of mood, reduced to rare occurrences.

Cravings decreased from uncontrolled to well-

integrative

understanding

of

modern

neuro-

gastroenterology

principles.

and

classical

Ayurvedic

From a biomedical perspective, overweight is

increasingly recognized as a disorder involving

dysregulation of the gut–brain axis, where

communication between the gastrointestinal system

and central nervous system influences appetite,

satiety, and emotional behavior^[26,7]. The patient in

this study exhibited classical features of gut–brain

regulated,

while

restlessness

(Chanchalata)

diminished considerably. Cognitive functions such

as concentration improved from poor to satisfactory

levels, reflecting better Manasika balance with

reduction in Rajas and Tamas.

Energy levels improved progressively, with the

patient transitioning from a lethargic state to

increased physical activity tolerance, indicating

dysregulation,

including

emotional

eating

irrespective of mood, cravings, restlessness, and

impaired concentration. Such symptoms are linked

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to altered signalling of hormones like ghrelin and

leptin, along with neurotransmitters such as

serotonin, a large proportion of which is

synthesized in the gut^[28,29]. Improvement in these

Rasayana, exerts detoxifying, antioxidant, and gut

microbiota-modulating effects, which are crucial in

metabolic disorders^[37]

.

The use of Lemon–Honey Ushnodaka aligns with

classical Ayurvedic recommendations for Ama

Pachana and Medohara action, promoting lipid

metabolism and enhancing digestion^[38]. The

polyherbal combination of Jeera–Ajwain–Saunf

provides a synergistic effect, improving digestive

fire and reducing gas formation, thereby directly

influencing gut function^[39]. Collectively, these

interventions work to restore Agni, eliminate Ama,

and normalize Dosha balance.

parameters

following

intervention

suggests

restoration of gut–brain signaling.

Ayurveda explains this pathogenesis through the

concept of Mandagni leading to Ama formation,

which disrupts normal metabolism and mental

clarity.

Adhmana (bloating), Alasya (lethargy), Saama

Mala, coated tongue, and excessive Meda

The

patient’s

initial

presentation—

accumulation—clearly indicated the presence of

Ama and impaired Agni. According to classical

texts, Sthoulya is a Santarpanajanya Vyadhi,

primarily involving Kapha dosha and Medodhatu

The timing of administration—morning on an

empty

stomach—is

particularly

significant.

Ayurveda emphasizes that Agni is most responsive

during this period, allowing optimal absorption and

therapeutic action. From a modern standpoint, early

morning intake of such formulations may influence

circadian rhythms, gut motility, and metabolic

priming for the day.

vriddhi^[30,31]

.

Additionally,

the

presence

of

emotional eating and restlessness reflects Manasika

imbalance with Rajas–Tamas predominance, which

further aggravates digestive dysfunction^[32]

.

The intervention focused on Agni Deepana, Ama

Pachana, and Kapha–Medohara action using seven

Ayurvedic detox drinks administered in a rotational

manner. Each component contributed through

A key outcome of this study was the reduction in

emotional eating, which highlights the role of detox

interventions in regulating the gut–brain axis.

Emerging evidence suggests that gut microbiota

influences neurotransmitter production and stress

response pathways^[40,41]. By improving gut health,

Ayurvedic detox drinks may indirectly regulate

mood and behavior, leading to better control over

cravings and eating patterns. This is further

supported by the observed improvement in sleep

specific

pharmacodynamic

actions.

Jeera

(Cuminum cyminum) enhances digestive enzyme

activity and improves metabolism, supporting

Agni^[33]. Ajwain (Trachyspermum ammi) acts as a

carminative

and

reduces

Vata-Kapha-induced

bloating^[34]. Saunf (Foeniculum vulgare) improves

gastrointestinal motility and reduces acidity,

thereby aiding digestion^[35]. Methi (Trigonella

foenum-graecum) has been shown to regulate

glucose metabolism and increase satiety, reducing

caloric intake^[36]. Triphala, a well-established

and

reduction

in

restlessness,

indicating

stabilization of the hypothalamic–pituitary–adrenal

(HPA) axis, which is known to be involved in

stress-induced obesity^[42]

.

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The gradual weight reduction of 3.8 kg over 30

days without drastic dietary restriction indicates a

sustainable and physiological approach. Unlike

crash dieting, which often leads to metabolic

slowdown and rebound weight gain, Ayurvedic

interventions focus on restoring metabolic balance.

This aligns with the principle of Nidana Parivarjana

(removal of causative factors) and correction of

underlying pathology rather than symptomatic

treatment.

microbiome analysis, and long-term follow-up to

validate these results.

Conclusion :

The present clinical case study demonstrates that a

structured 30-day regimen of Ayurvedic detox

drinks is effective in achieving sustainable weight

reduction and holistic metabolic correction through

modulation of the gut–brain axis. The intervention

resulted in a 3.8 kg reduction in body weight along

with significant improvement in digestive function,

reduction of bloating (Adhmana), normalization of

Another important aspect is the improvement in

Ojas (vital essence), reflected by enhanced energy

levels, better concentration, and overall well-being.

In Ayurveda, Ojas represents the end product of

bowel

habits,

and enhanced energy levels,

indicating successful Agni Deepana and Ama

Pachana.

proper

digestion

and

metabolism,

and

its

Notably, there was a marked decline in emotional

improvement

signifies

systemic health.

The

eating

behavior,

cravings,

restlessness,

and

transition from a state of lethargy and mental

dullness to increased vitality suggests successful

restoration of physiological and psychological

balance.

impaired concentration, reflecting restoration of

Manasika balance (reduction in Rajas–Tamas). This

highlights the pivotal role of Ayurvedic therapy not

only in correcting physical metabolism but also in

The findings of this study support the hypothesis

that Ayurvedic detox drinks act as modulators of

the gut–brain axis, integrating digestive, metabolic,

and psychological pathways. This approach offers

several advantages:

addressing

the

psychological

components

associated with overweight, thereby supporting the

concept of gut–brain axis regulation.

From an Ayurvedic perspective, the intervention

effectively targeted the core pathology of Sthoulya,



It is safe and cost-effective, using readily

available ingredients

namely

Medodhatu vriddhi, leading to improved metabolic

efficiency and overall well-being (Ojas

Mandagni,

Ama

accumulation,

and

It addresses both physical (Agni, Ama,

Meda) and mental (Rajas, Tamas) aspects

It provides a sustainable and non-invasive

strategy for weight management

enhancement). The use of simple, cost-effective,

and easily available detox drinks ensured high

patient compliance and safety, with no adverse

effects observed during the study period.

However, as this is a single-case study, the findings

cannot be generalized without further large-scale

clinical trials. Future research should focus on

controlled studies with biochemical markers,

In conclusion, Ayurvedic detox drinks offer a

practical, non-invasive, and integrative approach

for the management of overweight conditions by

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interactions. This approach aligns closely with

modern scientific understanding of the gut–brain

axis and underscores Ayurveda’s potential as a

preventive and therapeutic system in lifestyle

disorders. However, further large-scale, controlled

clinical studies are recommended to validate these

findings and establish broader clinical applicability.

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Declaration :

Conflict of Interest : None

ISSN: 2584-2757

DOI : https://doi.org/10.5281/zenodo.19597952

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